Prof. Yulong Li published a paper in PNAS with his collaborator.
Adenosine (Ado) is a critical neuromodulator, which has been implicated in many physiological and pathological processes such as sleep–wake regulation, learning and memory, epilepsy, and stroke. However, a fundamental question regarding the exact mechanism of Ado release in the brain is still far from clear, partly due to the lack of a sensitive method for its chemical- and cell-type-specific detection with high spatiotemporal resolution. Using a newly optimized genetically encoded fluorescent Ado sensor (GRABAdo); in combination with glutamate imaging, pharmacology, and genetic manipulation, we reveal the somatodendritic release of endogenous Ado with molecular details.
Original link: https://www.pnas.org/doi/10.1073/pnas.2212387120.
