个人介绍:

2003年师从赵进东院士于澳门威斯尼斯人橙色的获得生物科学学士学位，2004年至2009年师从诺贝尔奖得主Michael Brown和Joseph Goldstein教授于美国得克萨斯大学西南医学中心获得生物医学博士学位，2009年至2015年师从Marc Tessier-Lavigne教授先后在美国基因泰克公司和洛克菲勒大学从事博士后研究，2015年入职澳门威斯尼斯人橙色的担任博士生导师。

教育经历:

2004-2009，理学博士，美国得克萨斯大学西南医学中心
1999-2003，理学学士，澳门威斯尼斯人橙色的

工作经历:

2022-至今，外聘专家，澳门威斯尼斯人橙色的第三医院
2020-2023，合作研究员，北京脑科学与类脑研究中心
2019-2024，合作研究员，澳门威斯尼斯人橙色的－深圳湾实验室
2017-2022，博雅青年学者，澳门威斯尼斯人橙色的
2015-至今，研究员，生命科学联合中心／麦戈文脑科学研究所
2015-至今，博士生导师，澳门威斯尼斯人橙色的
2011-2015，博士后，美国洛克菲勒大学（The Rockefeller University）
2009-2011，博士后，美国基因泰克公司（Genentech Inc.）

      整合全组织成像、多组学分析、光/化学遗传学、动物疾病模型、人类临床样本等跨学科手段，专注于系统生理学的前沿交叉方向，探索不同疾病条件下神经系统、免疫系统、代谢系统、循环系统等的互作调控，在分子、细胞、器官、机体的多尺度层面开拓神经免疫（neuroimmunology）、神经代谢（neurometabolism）、免疫代谢（immunometabolism）等的创新概念和视角。曾获得海外高层次人才项目、优秀青年科学基金、杰出青年科学基金、原创探索计划等国家科研项目支持，并与生物制药产业建立合作转化，重点研究领域包括：
1. 脑疾病的代谢和免疫机制；
2. 免疫疾病的神经调节作用；
3. 代谢疾病的神经和免疫机制；
4. 肿瘤的神经免疫通路。

1. Publications since the current position:
- Representative papers (# corresponding author):
(1) Zhang M, Liu T, Yang J#. Skin neuropathy and immunomodulation in diseases. Fundamental Research. 2022 Sep. https://doi.org/10.1016/j.fmre.2022.08.016 (Review)
(2) Yang J#, Yaron A, Liu K. Editorial: Neuroimmune interactions in peripheral neuropathy. Frontiers in Molecular Neuroscience. 2022 May;15: 929081. (Editorial)
(3) Liu C, Yang J#. Enteric glial cells in immunological disorders of the gut. Frontiers in Cellular Neuroscience. 2022 April;16: 895871. (Review)
(4) Cao Y, Wang Y, Yang J#. NAD+-dependent mechanism of pathological axon degeneration. Cell Insight. 2022 April;1(2): 100019. (Review)
(5) Cao Y, Liu T, Zhou X, Fu W, Li J, Yang J#. 3D anatomy of autonomic innervations in immune organs of a non-human primate and the human. Fundamental Research. 2022 Mar. http://doi.org/10.1016/j.fmre.2022.03.002
(6) Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J#. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon. Protein Cell. 2021 Aug;12(8):621-638.
(7) Liu K, Yang L, Wang G, Liu J, Zhao X, Wang Y, Li J, Yang J#. Metabolic stress drives sympathetic neuropathy within the liver. Cell Metabolism. 2021 Mar 2;33(3):666-675.
(8) Jiang Y, Liu T, Lee CH, Chang Q, Yang J#, Zhang Z#. The NAD(+)-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. Nature. 2020 Dec;588(7839):658-663.
(9) Liu T, Yang L, Han X, Ding X, Li J, Yang J#. Local sympathetic innervations modulate the lung innate immune responses. Science Advances. 2020 May 13;6(20):eaay1497.
(10) Wang Q, Liu K, Yang L, Wang H, Yang J#. BoneClear: whole-tissue immunolabeling of the intact mouse bones for 3D imaging of neural anatomy and pathology. Cell Research. 2019 Oct;29(10):870-872.
(11) Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, Yang J#. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Reports. 2019 Jun 25;27(13):3799-3807.
(12) Zhou N, Liu K, Sun Y, Cao Y, Yang J#. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein Cell. 2019 Feb;10(2):87-103.
(13) Zhou N, Yang J#. Molecular Mechanism of Wallerian Degeneration. Chinese Bulletin of Life Sciences. 2017 Mar; 29(3): 245-250. (Review)

- Additional papers:
(1) Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z. Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discovery. 2022 Dec 28;8(1):141.
(2) Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z. Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8. Nature Communications. 2022 Aug 25;13(1):4988.
(3) Hu H, Cui YW, Yang J, Cao Y. Loss of the sympathetic signal produces sterile inflammation of the prostate. Frontiers in Molecular Neuroscience. 2022 May;15: 855376.
(4) Li X, Qi L, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H, Wei B. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nature Neuroscience. 2022 May;25(5):577-587.
(5) Qian K, Liu J, Cao Y, Yang J, Qiu S. Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice. Molecular Brain. 2021 Apr 19;14(1):71.
(6) Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K(+) channel regulates Parkinson`s pathology. Nature. 2021 Mar;591(7850):431-437.
(7) Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in ε-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice. Neuroscience Bulletin. 2021 Mar;37(3):311-322.
(8) Simon DJ, Pitts J, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tešić Mark M, Molina H, Tessier-Lavigne M. Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling. Cell. 2016 Feb 25;164(5):1031-45.

- Book chapters:
(1) Cao Y, Yang J. Whole-Tissue Immunolabeling and 3D Fluorescence Imaging to Visualize Axon Degeneration in the Intact, Unsectioned Mouse Tissues. In: Babetto E.(eds) Methods in Molecular Biology, 2020 Jun 11;2143: 223-232. Humana, New York, NY.
(2) Wang F, Yang J, He Z. Axon maintenance and degeneration. In: Rubenstein J., Rakic P., Chen B., Kwan K.Y., Kolodkin A., and Anton E.(eds) Comprehensive Developmental Neuroscience (Second Edition), 2020 Jun 5;217-230. Academic Press, Cambridge, MA.

2. Publications before the current position:
(1) Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15;160(1-2):161-76.
(2) Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.
(3) Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M. Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89.
(* authors contributed equally)
(4) Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5;110(10):4039-44.
(5) Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O`Leary DD, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. Journal of Neuroscience. 2012 Dec 5;32(49):17540-53.
(6) Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4.
(7) Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. American Journal of Physiology-Endocrinology and Metabolism. 2009 Jul;297(1):E134-41. (* authors contributed equally)
(8) Yang J*, Zhao TJ*, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 5;105(31):10750-5. (* authors contributed equally)
(9) Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96.
(10) Yang J, Dong C, Huang X, Zhao J. Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from DNA digestion solutions. Analytical Biochemistry. 2003 Nov 1;322(1):99-103.

实验室现有成员：

4 名博士后研究员

7 名博士研究生（生科院、CLS项目、PTN项目）

2 名实验室助理

已毕业博士研究生：

2023年6月：3 名（2017级生科院、2018级CLS项目）

2021年6月：2 名（2016级CLS项目、2016级生科院）

2020年6月：2 名（2015级CLS项目）

实验室成员主要荣誉：

1 人次国家自然科学基金青年科学基金

2 人次中国博士后科学基金

1 人次北京市自然科学基金青年项目

4 人次澳门威斯尼斯人橙色的CLS优秀博士后基金

1 人次北京市高校优秀博士毕业生

1 人次澳门威斯尼斯人橙色的优秀博士毕业生

1 人次澳门威斯尼斯人橙色的优秀博士学位论文

3 人次“国家奖学金”

10 人次“校长奖学金”

3 人次“专项学业奖学金”

2 人次“廖凯原奖学金”

1 人次“秦宛顺靳云汇奖学金”

1 人次“吕义长奖学金”

2 人次“苏州工业园区奖学金”

1 人次 Keystone Symposia Scholarship（美国）